abstract：:We have used discoidal reconstituted high density lipoproteins (rHDL) containing apolipoprotein (apo) A-I and dimyristoyl phosphatidylcholine (DMPC) as a tool to investigate the time sequence of the HDL-mediated inhibition of vascular cell adhesion molecule (VCAM)-1 and E-selectin expression in cytokine-activated huma...

journal_title：Atherosclerosis

authors： Clay MA,Pyle DH,Rye KA,Vadas MA,Gamble JR,Barter PJ

更新日期：2001-07-01 00:00:00

abstract：:The presence of Chlamydia pneumoniae in the human arterial system has mainly been determined in atherosclerotic plaque, whereas the adventitia has remained relatively unexplored. We assessed the presence of C. pneumoniae in all three vessel wall layers of coronary (n=72) and brachial (n=48) arteries in relation to loc...

journal_title：Atherosclerosis

authors： Vink A,Pasterkamp G,Poppen M,Schoneveld AH,de Kleijn DP,Roholl PJ,Fontijn J,Plomp S,Borst C

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:In acute myocardial infarction (AMI) treated conservatively or with thrombolysis, marked increases of C-reactive protein (CRP) and fibrinogen have been observed. No data are however available concerning a possible relation between CRP and fibrinogen levels on admission and markers of infarct size after obtai...

journal_title：Atherosclerosis

authors： De Sutter J,De Buyzere M,Gheeraert P,Van de Wiele C,Voet J,De Pauw M,Dierckx R,De Backer G,Taeymans Y

更新日期：2001-07-01 00:00:00

abstract：:The St. Thomas mixed hyperlipidaemic (SMHL) rabbit exhibits an inherited hyperlipidaemia similar to that seen in familial combined hyperlipidaemia (FCHL). In this study, we investigated whether the SMHL rabbit is insulin resistant, a condition often associated with FCHL. Six young and six mature combined hyperlipidaem...

journal_title：Atherosclerosis

authors： de Roos B,Caslake MJ,Ardern HA,Martin Benson G,Suckling KE,Packard CJ

更新日期：2001-06-01 00:00:00

abstract：:Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...

journal_title：Atherosclerosis

authors： Segev H,Honigman A,Rosen H,Leitersdorf E

更新日期：2001-06-01 00:00:00

abstract：:Cardiovascular risk is increased in patients with diabetic nephropathy. The aim of this study was to examine the relative impacts of albuminuria and renal failure, the two important features of diabetic nephropathy, on potentially atherogenic lipoprotein changes in this condition. The subjects were 160 non-diabetic he...

journal_title：Atherosclerosis

authors： Shoji T,Emoto M,Kawagishi T,Kimoto E,Yamada A,Tabata T,Ishimura E,Inaba M,Okuno Y,Nishizawa Y

更新日期：2001-06-01 00:00:00

abstract：:Cytosolic Phospholipase A(2) (cPLA(2)) has been implicated in receptor-mediated release of arachidonic acid from membrane phospholipids, the limiting step in prostacyclin and other eicosanoid production. Its activity is controlled by Ca(++) levels and enzymatically regulated phosphorylation. The purpose of this study ...

journal_title：Atherosclerosis

authors： Gudmundsdóttir IJ,Halldórsson H,Magnúsdóttir K,Thorgeirsson G

更新日期：2001-05-01 00:00:00

abstract：:Recent studies have clarified the significance of chemokines in cardiovascular diseases, such as development of atherosclerosis, atheromatous plaque rupture and restenosis after coronary angioplasty. We investigated changes in chemokine expression in the coronary circulation induced by percutaneous transluminal corona...

journal_title：Atherosclerosis

authors： Hojo Y,Ikeda U,Katsuki T,Mizuno O,Fukazawa H,Fujikawa H,Shimada K

更新日期：2001-05-01 00:00:00

abstract：:The arterial endothelial intercellular cleft (AEC) and its associated junctional complex (JC) are the determinants of permeability to macromolecules. This study analyzed frequencies of AEC and JC profile types in the rat thoracic aorta at 1 and 12 months after feeding the animals with a normal or a high-cholesterol di...

journal_title：Atherosclerosis

authors： Lee WC,Chao WT,Yang VC

更新日期：2001-04-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of fluvastatin on the microcirculation of patients with hyperlipidaemia (low-density lipoprotein cholesterol > 160 mg/dL, triglycerides < 350 mg/dl) inadequately controlled by diet. After a dietary run-in of 4 weeks, patients were randomised in a double-blind stu...

journal_title：Atherosclerosis

authors： Haak E,Abletshauser C,Weber S,Goedicke C,Martin N,Hermanns N,Lackner K,Kusterer K,Usadel KH,Haak T

更新日期：2001-04-01 00:00:00

abstract：:Apolipoprotein (apo) E is a multifunctional protein that can act as a ligand for lipoprotein receptors. The receptor-mediated clearance of the triglyceride-rich lipoproteins (TRL) chylomicrons and VLDL from plasma is, in part, dependent on apo E. Enrichment of VLDL with apo E is thought to enhance receptor-mediated cl...

journal_title：Atherosclerosis

authors： Millar JS,Lichtenstein AH,Ordovas JM,Dolnikowski GG,Schaefer EJ

更新日期：2001-04-01 00:00:00

abstract：:Mitral annulus calcification (MAC) is a chronic, non-inflammatory, degenerative process of the fibrous support structure of the mitral valve. It occurs more often in women and the elderly. MAC is associated with known atherosclerotic risk factors such as diabetes mellitus, hypertension and hypercholesterolemia. It is ...

journal_title：Atherosclerosis

authors： Adler Y,Fink N,Spector D,Wiser I,Sagie A

更新日期：2001-03-01 00:00:00

abstract：:Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...

journal_title：Atherosclerosis

authors： Lindstedt L,Lee M,Kovanen PT

更新日期：2001-03-01 00:00:00

abstract：AIMS:To compare cardiovascular risk factors in diabetic subjects of different ethnic groups, and between new and known diabetic subjects, in the Singapore National Health Survey '92. METHODS:Disproportionate stratified sampling followed by systematic sampling were used in 3568 (total) respondents of whom 2743 were non...

journal_title：Atherosclerosis

authors： Tan CE,Emmanuel SC,Tan BY,Tai ES,Chew SK

更新日期：2001-03-01 00:00:00

abstract：:The proband is a 50 year-old woman born from a consanguineous marriage. She has been suffering from angina pectoris since the age of 38 and underwent coronary bypass surgery for three-vessel disease at 48. The presence of low plasma levels of total cholesterol and high density lipoprotein (HDL) cholesterol (2.4 and 0....

journal_title：Atherosclerosis

authors： Bertolini S,Pisciotta L,Seri M,Cusano R,Cantafora A,Calabresi L,Franceschini G,Ravazzolo R,Calandra S

更新日期：2001-02-15 00:00:00

abstract：:Inflammation is thought to play a central role in the etiology and outcome of atherosclerosis. Animal studies as well as in vitro and in vivo human studies suggest that host factors modulate the magnitude and extent of inflammatory responses. We investigated familial aggregation of three systemic markers of inflammati...

journal_title：Atherosclerosis

authors： Pankow JS,Folsom AR,Cushman M,Borecki IB,Hopkins PN,Eckfeldt JH,Tracy RP

更新日期：2001-02-15 00:00:00

abstract：:Low-density lipoprotein (LDL) concentration in plasma is an important predictor for atherosclerosis, and desialylated LDL has been proposed to be particularly atherogenic. Atherosclerosis is also associated with vascular endothelial dysfunction. We therefore wished to test the hypothesis that removal of sialic acid re...

journal_title：Atherosclerosis

authors： Stratton PD,Lumb PJ,Paganga G,Crook MA,Ferro A

更新日期：2001-02-01 00:00:00

abstract：:The formation of atherosclerotic lesions requires the migration of vascular smooth muscle cells from the media into the intima of the artery and their proliferation. These events, which are preceded and accompanied by inflammation, are modulated by integrin receptors linking vascular smooth muscle cells to extracellul...

journal_title：Atherosclerosis

authors： Barillari G,Albonici L,Incerpi S,Bogetto L,Pistritto G,Volpi A,Ensoli B,Manzari V

更新日期：2001-02-01 00:00:00

abstract：:Oxidized low-density lipoproteins (LDL) impair endothelium-dependent dilation and constrict arteries. This study examined possible relation of the circulating plasma levels of Ox-LDL to coronary spastic angina (CSA). The plasma levels of Ox-LDL were measured by ELISA in 37 consecutive patients with CSA and normal coro...

journal_title：Atherosclerosis

authors： Kugiyama K,Sugiyama S,Soejima H,Kawano H,Sakamoto T,Takazoe K,Ogawa H,Doi H,Yasue H

更新日期：2001-02-01 00:00:00

abstract：:High-density lipoproteins (HDL) have several antiatherogenic actions, including the ability to sequester cellular cholesterol, to protect low-density lipoproteins from oxidation and to inhibit platelet aggregation. An early event in atherogenesis is the adhesion and recruitment of blood monocytes, a process mediated b...

journal_title：Atherosclerosis

authors： Stannard AK,Khan S,Graham A,Owen JS,Allen SP

更新日期：2001-01-01 00:00:00

abstract：:A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. The risk associated with the ...

journal_title：Atherosclerosis

authors： Steeds RP,Wardle A,Smith PD,Martin D,Channer KS,Samani NJ

更新日期：2001-01-01 00:00:00

abstract：:Hypercholesterolemia (HC) induces alterations in systemic vascular reactivity, which can manifest as an attenuated endothelium-dependent relaxation, partly consequent to an impairment in nitric oxide (NO) activity. To determine whether experimental HC has a similar effect on renal vascular function, renal artery segme...

journal_title：Atherosclerosis

authors： Stulak JM,Lerman A,Caccitolo JA,Wilson SH,Romero JC,Schaff HV,Rodriguez Porcel M,Lerman LO

更新日期：2001-01-01 00:00:00

abstract：:Inflammation is one of the most important mechanisms that contribute to coronary artery disease (CAD). One of the micro-organisms that is mentioned as a source of the inflammation is Chlamydia pneumoniae. In this study, we investigated the relationship between titres of IgG and IgA antibodies to C. pneumoniae and the ...

journal_title：Atherosclerosis

authors： de Maat MP,Ossewaarde JM,Verheggen PW,Kluft C,Cats VM,Haverkate F

更新日期：2000-12-01 00:00:00

abstract：:Smooth muscle cell (SMC) proliferation is a prominent feature of intimal hyperplasia after percutaneous coronary interventions. p27 is a critical regulator of cell proliferation. Our aims were to analyze the time course of p27 expression, Ki67 proliferative index, and apoptosis after angioplasty in the porcine coronar...

journal_title：Atherosclerosis

authors： Roque M,Cordon-Cardo C,Fuster V,Reis ED,Drobnjak M,Badimon JJ

更新日期：2000-12-01 00:00:00

abstract：:Abundant data is present to implicate oxidatively modified low-density lipoprotein (oxLDL) in enhanced atherogenesis. Among the factors involved in LDL oxidation, an important role has been attributed to human 15-lipoxygenase (LO) and its murine analog 12-LO. The expression of these peroxidizing enzymes is under the c...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Shaish A,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-12-01 00:00:00

abstract：:Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...

journal_title：Atherosclerosis

authors： Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

更新日期：2000-11-01 00:00:00

abstract：:The defects in the internal elastic lamina (IEL) have been proposed to be important for the migration of smooth muscle cells into the intima during atherosclerosis. We investigated the association of a genetic factor--apolipoprotein E (apoE) genotype--with the number of gaps in the IEL of the artery wall in 123 consec...

journal_title：Atherosclerosis

authors： Ilveskoski E,Järvinen O,Sisto T,Karhunen PJ,Laippala P,Lehtimäki T

更新日期：2000-11-01 00:00:00

abstract：:Role of enterohepatic cholesterol metabolism in obesity-induced increase of cholesterol synthesis was studied in healthy lean (BMI <24) and overweight (BMI >31) subjects by measuring serum lipids (including plant sterols, cholestanol and cholesterol precursors), cholesterol absorption % (double-label method), sterol b...

journal_title：Atherosclerosis

authors： Miettinen TA,Gylling H

更新日期：2000-11-01 00:00:00

abstract：:There are no definitive explanations as to why individuals with hypercholesterolemia, a major cardiovascular risk factor, respond differently to dietary change. Fifty five free-living individuals completed a double crossover trial with two dietary regimens, a high saturated fat diet (providing 21% energy from saturate...

journal_title：Atherosclerosis

authors： Wallace AJ,Mann JI,Sutherland WH,Williams S,Chisholm A,Skeaff CM,Gudnason V,Talmud PJ,Humphries SE

更新日期：2000-10-01 00:00:00

abstract：:High serum concentrations of soluble adhesion molecules are present in diabetics, but whether similar levels are present in patients with impaired glucose tolerance (IGT) is unclear. We measured serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), an...

journal_title：Atherosclerosis

authors： Matsumoto K,Miyake S,Yano M,Ueki Y,Tominaga Y

更新日期：2000-10-01 00:00:00

abstract：:To study the association of alcohol consumption and lipid-based cardiovascular risk factors among middle-age women, cross-sectional analysis among 274 middle-aged healthy women with different drinking habits and a follow-up analysis of alcoholic women during abstinence was performed. Serum total cholesterol, low and h...

journal_title：Atherosclerosis

authors： Sillanaukee P,Koivula T,Jokela H,Pitkäjärvi T,Seppä K

更新日期：2000-10-01 00:00:00

abstract：:The involvement of endothelium-derived hyperpolarizing factor (EDHF) in the protective effect of 17beta-estradiol was investigated on the phenylephrine-precontracted carotid artery from cholesterol fed rabbits. Animals were fed for 8 weeks as follows: control group, standard chow; (control+estradiol) group, standard c...

journal_title：Atherosclerosis

authors： Ghanam K,Ea-Kim L,Javellaud J,Oudart N

更新日期：2000-09-01 00:00:00

abstract：:A single centre randomised placebo-controlled trial was performed to assess the 2-year effects of hormone replacement therapy compared to placebo on mechanical arterial properties in 99 perimenopausal women recruited from the general population. The trial was double-blind with respect to a sequential combined regimen ...

journal_title：Atherosclerosis

authors： Westendorp IC,de Kleijn MJ,Bots ML,Bak AA,Planellas J,Coelingh Bennink HJ,Hofman A,Grobbee DE,Witteman JC

更新日期：2000-09-01 00:00:00

abstract：:The possible role of four candidate genes in lipid and lipoprotein response to diet was examined in 214 members of two large kibbutz settlements in Israel. Four site polymorphisms (signal peptide insertion/deletion, XbaI, EcoRI and MspI) of the apo B gene, the common apo E genotypes, three common mutations (T-93G, S44...

journal_title：Atherosclerosis

authors： Friedlander Y,Leitersdorf E,Vecsler R,Funke H,Kark J

更新日期：2000-09-01 00:00:00

abstract：:Oxygen free radicals as well as immunological reactions have been suggested to play important roles in atherogenesis and other pathological processes of the blood vessel wall. We have previously shown that the vascular wall contains exceptionally large amounts of extracellular superoxide dismutase (EC-SOD) and that th...

journal_title：Atherosclerosis

authors： Strålin P,Marklund SL

更新日期：2000-08-01 00:00:00

abstract：:We describe the characterization of a novel mutation in the low density lipoprotein receptor (LDL-R) gene in a patient with true homozygous familial hypercholesterolemia (FH). The combined use of denaturing gradient gel electrophoresis (DGGE) and sequencing of genomic DNA revealed a guanine to adenine base substitutio...

journal_title：Atherosclerosis

authors： Nauck MS,Scharnagl H,Nissen H,Schürmann C,Matern D,Nauck MA,Wieland H,März W

更新日期：2000-08-01 00:00:00

abstract：:Despite numerous studies, the precise role of dietary n-6 polyunsaturated fatty acids in the pathogenesis of atherosclerosis remains controversial. It has been shown that feeding an n-6-enriched diet resulted in decreased atherosclerosis in African green monkeys and was associated with a reduction in LDL levels. Howev...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-06-01 00:00:00

abstract：:Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...

journal_title：Atherosclerosis

authors： Schwertner HA,Fischer JR Jr

更新日期：2000-06-01 00:00:00

abstract：:We investigated the effects of estrogen and simvastatin, administered both alone and in combination, on the plasma lipid levels and lipoprotein-related enzymes in 45 postmenopausal women with type IIa hypercholesterolemia. They received 0.625 mg conjugated equine estrogen (n=15), 5 mg simvastatin (n=15), or the combin...

journal_title：Atherosclerosis

authors： Wakatsuki A,Okatani Y,Ikenoue N

更新日期：2000-05-01 00:00:00

abstract：:Obesity is commonly associated with high rates of cardiovascular disease (CVD). Weight loss in obese subjects reduces risk factors for CVD but this response is not uniform. Genetic factors could be involved in this variability. The 360His polymorphism of apolipoproteinA-IV (apoA-IV) influences the lipid response to fa...

journal_title：Atherosclerosis

authors： Heilbronn LK,Noakes M,Morris AM,Kind KL,Clifton PM

更新日期：2000-05-01 00:00:00